Orthodontic Protocol

Q: 51% with BOP<10%

N = 200 · RANDOMIZED, PEER-REVIEWED · 2026 In Stage I–III periodontitis patients on supportive periodontal care (SPC), reductions in key measurements were greater with home-applied dual-light therapy as an adjunct to SPC than with SPC alone. At 6 months, 51% of participants with SPC+dual-light had BOP<10%, versus 23% with SPC alone. At 6 months, 63% had visible plaque (VPI) <10% with SPC+dual-light, versus 38% with SPC alone. The number of sites with PPD ≥4 mm was also lower with SPC+dual-light. Pakarinen S et al. Journal of Periodontology. 2026. DOI: 10.1002/jper.70082

Q: PISA reduction 50.4%

N = 31 · RANDOMIZED, MULTI-CENTER, PEER-REVIEWED (IN PRESS) · 2026 In a multicenter, Stage I–III periodontitis study on supportive periodontal care (SPC), inflammation and plaque reduction were greater with SPC+home-applied dual-light therapy than with SPC alone. At 6 months, the inflamed periodontal epithelial surface area (PISA) reduced from 385 to 191 mm2 (p=0.034) with SPC-dual-light, versus 226 to 174 mm2 (p=non-significant). Mean visual plaque index (VPI) reduced from 20.9 to 10.6% with SPC-dual-light, versus 19.6 to 15.7% with SPC only. Tegelberg P et al. Preprint available at medRxiv. 2025. DOI: 10.1101/2025.03.25.25324596

Q: Plaque reduction -21.2%

N = 30 · CROSSOVER, PEER-REVIEWED · 2025 In a crossover study of healthy adults aged 20–25, when participants were using Lumoral, the Greene-Vermilion plaque scores reduced by 21.2% (significant reduction, p < 0.0001), and 6.5% (p = 0.107) with conventional home-care. This is the closest age profile to many aligner patients. Gusseva L, Lill LL. Journal of Dentistry. 2026. DOI: 10.1016/j.dent.2026.106641

The orthodontic appliance environment favors plaque maturation, inflammatory changes, and enamel demineralization between visits

A clear aligner, worn 22 hours a day, is not a neutral device. Like other orthodontic appliances, including braces and accessories, it creates plaque-retentive areas where oral hygiene becomes more demanding. It seals the tooth surface, reduces salivary clearance over the enamel, and creates a microenvironment where plaque accumulates at the edges of the appliances, in cervical zones, and in the interproximal spaces between teeth.

Aligners create a closed biofilm environment and braces are difficult to keep completely clean.

22 hours of daily aligner wear reduces natural saliva clearance and increases the risk of plaque accumulation, inflammation, and demineralization between control visits.

White spot lesions
Demineralization around aligner edges can compromise the aesthetic end result.
Gingival inflammation
Inflammation affects tissue, comfort, and aligner adaptation.
Tracking loss
Inflamed tissue can reduce tracking accuracy and increase the need for refinements.
Caries risk
Acidogenic bacteria under the aligner increase the risk of caries.

Long-term risk

The risk lies in the residual biofilm

Lumoral addresses a clinically significant gap in orthodontic hygiene: the residual biofilm that remains between visits despite tooth brushing. Used as a supplementary home treatment, it is intended to reduce plaque accumulation before it progresses to marginal inflammation, acid-driven demineralisation, and the tissue changes that can complicate aligner tracking and control of orthodontic treatment.

Lumoral®

Biofilm control designed for daily use

Lumoral combines antibacterial blue light with photodynamic therapy to control plaque and inflammatory load throughout the aligner treatment.

ABL · 405 nm

Targets plaque-associated bacteria using antibacterial blue light.

APDT · 810 nm + ICG

ICG binds selectively to plaque and is activated by near-infrared light.

No resistance · No staining

Suitable for continuous use throughout the treatment period.

An alternative to long-term chlorhexidine use

Problems with CHX

staining
dysgeusia
microbiome disruption
poor compliance

Lumoral®

no staining
no resistance
no microbiome disruption
designed for long-term use
compatible with aligners

85% maintained BOP ≤10%

N = 40 · RANDOMIZED · SUBMITTED MANUSCRIPT · DATA ON FILE

In a single-site, randomized, assessor-blinded clinical study of adolescents starting fixed orthodontic treatment, home-applied dual-light aPDT used alongside standard hygiene supported better plaque and inflammation control over 12 weeks than standard hygiene alone. VPI decreased 1.8× more with dual-light aPDT than in controls (-7.65% vs -4.22%). A higher proportion of participants in the dual-light group maintained BOP ≤10% compared with controls (85% vs 58%), and fewer participants showed an increase in BOP values (35.0% vs 78.9%).

Hashemi-Elses et al. ClinicalTrials.gov ID: NCT05825742

51% with BOP<10%

N = 200 · RANDOMIZED, PEER-REVIEWED · 2026

In Stage I–III periodontitis patients on supportive periodontal care (SPC), reductions in key measurements were greater with home-applied dual-light therapy as an adjunct to SPC than with SPC alone. At 6 months, 51% of participants with SPC+dual-light had BOP<10%, versus 23% with SPC alone. At 6 months, 63% had visible plaque (VPI) <10% with SPC+dual-light, versus 38% with SPC alone. The number of sites with PPD ≥4 mm was also lower with SPC+dual-light.

Pakarinen S et al. Journal of Periodontology. 2026. DOI: 10.1002/jper.70082

PISA reduction 50.4%

N = 31 · RANDOMIZED, MULTI-CENTER, PEER-REVIEWED (IN PRESS) · 2026

In a multicenter, Stage I–III periodontitis study on supportive periodontal care (SPC), inflammation and plaque reduction were greater with SPC+home-applied dual-light therapy than with SPC alone. At 6 months, the inflamed periodontal epithelial surface area (PISA) reduced from 385 to 191 mm2 (p=0.034) with SPC-dual-light, versus 226 to 174 mm2 (p=non-significant). Mean visual plaque index (VPI) reduced from 20.9 to 10.6% with SPC-dual-light, versus 19.6 to 15.7% with SPC only.

Tegelberg P et al. Preprint available at medRxiv. 2025. DOI: 10.1101/2025.03.25.25324596

Plaque reduction -21.2%

N = 30 · CROSSOVER, PEER-REVIEWED · 2025

In a crossover study of healthy adults aged 20–25, when participants were using Lumoral, the Greene-Vermilion plaque scores reduced by 21.2% (significant reduction, p < 0.0001), and 6.5% (p = 0.107) with conventional home-care. This is the closest age profile to many aligner patients.

Gusseva L, Lill LL. Journal of Dentistry. 2026. DOI: 10.1016/j.dent.2026.106641